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Mitochondrial genome sequence diversity of Indian Plasmodium falciparum isolates.

ABSTRACT: We have analysed the whole mitochondrial (mt) genome sequences (each ~6 kilo nucleotide base pairs in length) of four field isolates of the malaria parasite Plasmodium falciparum collected from different locations in India. Comparative genomic analyses of mt genome sequences revealed three novel India-specific single nucleotide polymorphisms. In general, high mt genome diversity was found in Indian P. falciparum, at a level comparable to African isolates. A population phylogenetic tree placed the presently sequenced Indian P. falciparum with the global isolates, while a previously sequenced Indian isolate was an outlier. Although this preliminary study is limited to a few numbers of isolates, the data have provided fundamental evidence of the mt genome diversity and evolutionary relationships of Indian P. falciparum with that of global isolates.

SUBMITTER: Tyagi S

PROVIDER: S-EPMC4155855 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature

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Mitochondrial genome sequence diversity of Indian Plasmodium falciparum isolates.

Tyagi Suchi S Pande Veena V Das Aparup A

Memorias do Instituto Oswaldo Cruz 20140701 4

We have analysed the whole mitochondrial (mt) genome sequences (each ~6 kilo nucleotide base pairs in length) of four field isolates of the malaria parasite Plasmodium falciparum collected from different locations in India. Comparative genomic analyses of mt genome sequences revealed three novel India-specific single nucleotide polymorphisms. In general, high mt genome diversity was found in Indian P. falciparum, at a level comparable to African isolates. A population phylogenetic tree placed th ...[more]

PMID: 25075789

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Mitochondrial genome sequence diversity of Indian Plasmodium falciparum isolates.

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Mitochondrial genome sequence diversity of Indian Plasmodium falciparum isolates.

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