Ontology highlight
ABSTRACT:
SUBMITTER: Kenniston JA
PROVIDER: S-EPMC4156074 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Kenniston Jon A JA Faucette Ryan R RR Martik Diana D Comeau Stephen R SR Lindberg Allison P AP Kopacz Kris J KJ Conley Gregory P GP Chen Jie J Viswanathan Malini M Kastrapeli Niksa N Cosic Janja J Mason Shauna S DiLeo Mike M Abendroth Jan J Kuzmic Petr P Ladner Robert C RC Edwards Thomas E TE TenHoor Christopher C Adelman Burt A BA Nixon Andrew E AE Sexton Daniel J DJ Sexton Daniel J DJ
The Journal of biological chemistry 20140626 34
Plasma kallikrein (pKal) proteolytically cleaves high molecular weight kininogen to generate the potent vasodilator and the pro-inflammatory peptide, bradykinin. pKal activity is tightly regulated in healthy individuals by the serpin C1-inhibitor, but individuals with hereditary angioedema (HAE) are deficient in C1-inhibitor and consequently exhibit excessive bradykinin generation that in turn causes debilitating and potentially fatal swelling attacks. To develop a potential therapeutic agent fo ...[more]