A combined computational-experimental approach predicts human microRNA targets.
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ABSTRACT:
SUBMITTER: Kiriakidou M
PROVIDER: S-EPMC415641 | biostudies-literature | 2004 May
REPOSITORIES: biostudies-literature
Publications
A combined computational-experimental approach predicts human microRNA targets.
Kiriakidou Marianthi M Nelson Peter T PT Kouranov Andrei A Fitziev Petko P Bouyioukos Costas C Mourelatos Zissimos Z Hatzigeorgiou Artemis A
Genes & development 20040506 10
A new paradigm of gene expression regulation has emerged recently with the discovery of microRNAs (miRNAs). Most, if not all, miRNAs are thought to control gene expression, mostly by base pairing with miRNA-recognition elements (MREs) found in their messenger RNA (mRNA) targets. Although a large number of human miRNAs have been reported, many of their mRNA targets remain unknown. Here we used a combined bioinformatics and experimental approach to identify important rules governing miRNA-MRE reco ...[more]
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