Ontology highlight
ABSTRACT:
SUBMITTER: Tighiouart M
PROVIDER: S-EPMC4156522 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Tighiouart Mourad M Piantadosi Steven S Rogatko André A
Statistics in medicine 20140513 22
We present a Bayesian adaptive design for dose finding of a combination of two drugs in cancer phase I clinical trials. The goal is to estimate the maximum tolerated dose (MTD) as a curve in the two-dimensional Cartesian plane. We use a logistic model to describe the relationship between the doses of the two agents and the probability of dose limiting toxicity. The model is re-parameterized in terms of parameters clinicians can easily interpret. Trial design proceeds using univariate escalation ...[more]