Ontology highlight
ABSTRACT:
SUBMITTER: Endres BT
PROVIDER: S-EPMC4156702 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Endres Bradley T BT Priestley Jessica R C JR Palygin Oleg O Flister Michael J MJ Hoffman Matthew J MJ Weinberg Brian D BD Grzybowski Michael M Lombard Julian H JH Staruschenko Alexander A Moreno Carol C Jacob Howard J HJ Geurts Aron M AM
Proceedings of the National Academy of Sciences of the United States of America 20140818 35
PLEKHA7 (pleckstrin homology domain containing family A member 7) has been found in multiple studies as a candidate gene for human hypertension, yet functional data supporting this association are lacking. We investigated the contribution of this gene to the pathogenesis of salt-sensitive hypertension by mutating Plekha7 in the Dahl salt-sensitive (SS/JrHsdMcwi) rat using zinc-finger nuclease technology. After four weeks on an 8% NaCl diet, homozygous mutant rats had lower mean arterial (149 ± 9 ...[more]