Ontology highlight
ABSTRACT:
SUBMITTER: Li G
PROVIDER: S-EPMC4157339 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Li Guanglei G Simon Melissa J MJ Cancel Limary M LM Shi Zhong-Dong ZD Ji Xinying X Tarbell John M JM Morrison Barclay B Fu Bingmei M BM
Annals of biomedical engineering 20100402 8
The blood-brain barrier (BBB) is a major obstacle for drug delivery to the brain. To seek for in vitro BBB models that are more accessible than animals for investigating drug transport across the BBB, we compared four in vitro cultured cell models: endothelial monoculture (bEnd3 cell line), coculture of bEnd3 and primary rat astrocytes (coculture), coculture with collagen type I and IV mixture, and coculture with Matrigel. The expression of the BBB tight junction proteins in these in vitro model ...[more]