Ontology highlight
ABSTRACT:
SUBMITTER: Xu Q
PROVIDER: S-EPMC4157861 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Xu Qingping Q Deller Marc C MC Nielsen Tine K TK Grant Joanna C JC Lesley Scott A SA Elsliger Marc-André MA Deacon Ashley M AM Wilson Ian A IA
PloS one 20140908 9
Kanadaptin is a nuclear protein of unknown function that is widely expressed in mammalian tissues. The crystal structure of the forkhead-associated (FHA) domain of human kanadaptin was determined to 1.6 Å resolution. The structure reveals an asymmetric dimer in which one monomer is complexed with a phosphopeptide mimic derived from a peptide segment from the N-terminus of a symmetry-related molecule as well as a sulfate bound to the structurally conserved phosphothreonine recognition cleft. This ...[more]