Dataset Information

Screening of clock gene polymorphisms demonstrates association of a PER3 polymorphism with morningness-eveningness preference and circadian rhythm sleep disorder.

ABSTRACT: A system of self-sustained biological clocks controls the 24-h rhythms of behavioral and physiological processes such as the sleep-wake cycle. The circadian clock system is regulated by transcriptional and translational negative feedback loops of multiple clock genes. Polymorphisms in circadian clock genes have been associated with morningness-eveningness (diurnal) preference, familial advanced sleep phase type (ASPT), and delayed sleep phase type (DSPT). We genotyped single-nucleotide polymorphisms in circadian clock genes in 182 DSPT individuals, 67 free-running type (FRT) individuals, and 925 controls. The clock gene polymorphisms were tested for associations with diurnal preference and circadian rhythm sleep disorder (CRSD) phenotypes. The PER3 polymorphism (rs228697) was significantly associated with diurnal preference and the FRT phenotype. The minor allele of rs228697 was more prevalent in evening types than in morning types (sex-adjusted odds ratio (OR), 2.483, Bonferroni-corrected P = 0.012) and in FRT individuals compared with the controls (age- and sex-adjusted OR, 2.021, permutated P = 0.017). Our findings support the notion that PER3 polymorphisms could be a potential genetic marker for an individual's circadian and sleep phenotypes.

SUBMITTER: Hida A

PROVIDER: S-EPMC4158573 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Screening of clock gene polymorphisms demonstrates association of a PER3 polymorphism with morningness-eveningness preference and circadian rhythm sleep disorder.

Hida Akiko A Kitamura Shingo S Katayose Yasuko Y Kato Mie M Ono Hiroko H Kadotani Hiroshi H Uchiyama Makoto M Ebisawa Takashi T Inoue Yuichi Y Kamei Yuichi Y Okawa Masako M Takahashi Kiyohisa K Mishima Kazuo K

Scientific reports 20140909

A system of self-sustained biological clocks controls the 24-h rhythms of behavioral and physiological processes such as the sleep-wake cycle. The circadian clock system is regulated by transcriptional and translational negative feedback loops of multiple clock genes. Polymorphisms in circadian clock genes have been associated with morningness-eveningness (diurnal) preference, familial advanced sleep phase type (ASPT), and delayed sleep phase type (DSPT). We genotyped single-nucleotide polymorph ...[more]

PMID: 25201053

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Project description:The aim of this study was to develop a questionnaire to conveniently assess the diurnal preferences of physical activity (PA) in Japanese university students. A total of 219 subjects completed our novel Morningness-eveningness Exercise Preference Questionnaire (MEEPQ). The MEEPQ consisted of 30 items (15 items for the morning and the same 15 items for the evening) rated on a 5-point Likert scale concerning their preference for participating in PA in the morning and evening. The morning score (MS) and evening score (ES) were determined by summing each of the respective 15 items. The internal consistency and construct validity were assessed, and a factor analysis was conducted. To examine the external validity of the MEEPQ, participants wore an accelerometer for seven consecutive days to measure their PA levels objectively. Finally, the test-retest reliability was evaluated at a one-month interval. The MEEPQ showed excellent internal consistency (Cronbach's alpha = 0.896) and construct validity (morning KMO = 0.913, evening KMO = 0.875). A factor analysis showed a three-factor structure involving Physical Wellness (MEEPQ-W), Psychological Well-Being (MEEPQ-P) and Exercise Barrier (MEEPQ-B). The percent of variance was largest for MEEPQ-W in the morning (45.2%) and MEEPQ-P in the evening (40.8%). Test-retest showed that MEEPQ scores had fair repeatability. Significant and positive associations between scores and objectively measured PA levels were found in the MS and 6-9 AM PA and in the ES and 6-9 PM and 9 PM- 0 AM PA (all p<0.05). In summary, the novel MEEPQ showed relatively good agreement and thus can be used for Japanese university student samples. In the MEEPQ, three factors (the physical wellness, psychological well-being and exercise barrier) contributed to a morning or evening PA preference. The summed scores were significantly associated with the objectively measured PA levels in both the morning and evening. Therefore the MEEPQ appears to be a suitable tool for assessing diurnal PA preferences.

Dataset Information

Screening of clock gene polymorphisms demonstrates association of a PER3 polymorphism with morningness-eveningness preference and circadian rhythm sleep disorder.

Publications

Screening of clock gene polymorphisms demonstrates association of a PER3 polymorphism with morningness-eveningness preference and circadian rhythm sleep disorder.

Similar Datasets

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