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Lack of association between PER3 variable number tandem repeat and circadian rhythm sleep-wake disorders.

ABSTRACT: Circadian rhythm sleep-wake disorders (CRSWDs) are characterized by disturbed sleep-wake patterns. We genotyped a PER3 variable number tandem repeat (VNTR) in 248 CRSWD individuals and 925 controls and found no significant association between the VNTR and CRSWDs or morningness-eveningness (diurnal) preferences in the Japanese population. Although the VNTR has been associated with circadian and sleep phenotypes in some other populations, the polymorphism may not be a universal genetic marker.

SUBMITTER: Hida A 

PROVIDER: S-EPMC6043536 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Lack of association between <i>PER3</i> variable number tandem repeat and circadian rhythm sleep-wake disorders.

Hida Akiko A   Kitamura Shingo S   Kadotani Hiroshi H   Uchiyama Makoto M   Ebisawa Takashi T   Inoue Yuichi Y   Kamei Yuichi Y   Mishima Kazuo K  

Human genome variation 20180712

Circadian rhythm sleep-wake disorders (CRSWDs) are characterized by disturbed sleep-wake patterns. We genotyped a <i>PER3</i> variable number tandem repeat (VNTR) in 248 CRSWD individuals and 925 controls and found no significant association between the VNTR and CRSWDs or morningness-eveningness (diurnal) preferences in the Japanese population. Although the VNTR has been associated with circadian and sleep phenotypes in some other populations, the polymorphism may not be a universal genetic mark  ...[more]

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