Structural analysis of diheme cytochrome c by hydrogen-deuterium exchange mass spectrometry and homology modeling.
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ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC4159202 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
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Structural analysis of diheme cytochrome c by hydrogen-deuterium exchange mass spectrometry and homology modeling.
Zhang Ying Y Majumder Erica L-W EL Yue Hai H Blankenship Robert E RE Gross Michael L ML
Biochemistry 20140827 35
A lack of X-ray or nuclear magnetic resonance structures of proteins inhibits their further study and characterization, motivating the development of new ways of analyzing structural information without crystal structures. The combination of hydrogen-deuterium exchange mass spectrometry (HDX-MS) data in conjunction with homology modeling can provide improved structure and mechanistic predictions. Here a unique diheme cytochrome c (DHCC) protein from Heliobacterium modesticaldum is studied with b ...[more]
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