Ontology highlight
ABSTRACT:
SUBMITTER: Seetaloo N
PROVIDER: S-EPMC9204700 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
Seetaloo Neeleema N Kish Monika M Phillips Jonathan J JJ
Analytical chemistry 20220309 11
Hydrogen/deuterium-exchange mass spectrometry (HDX-MS) experiments on protein structures can be performed at three levels: (1) by enzymatically digesting labeled proteins and analyzing the peptides (bottom-up), (2) by further fragmenting peptides following digestion (middle-down), and (3) by fragmenting the intact labeled protein (top-down) using soft gas-phase fragmentation methods, such as electron transfer dissociation (ETD). However, to the best of our knowledge, the software packages curren ...[more]