LeoA, B and C from enterotoxigenic Escherichia coli (ETEC) are bacterial dynamins.
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ABSTRACT:
SUBMITTER: Michie KA
PROVIDER: S-EPMC4159319 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
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LeoA, B and C from enterotoxigenic Escherichia coli (ETEC) are bacterial dynamins.
Michie Katharine A KA Boysen Anders A Low Harry H HH Møller-Jensen Jakob J Löwe Jan J
PloS one 20140909 9
Escherichia coli (ETEC) strain H10407 contains a GTPase virulence factor, LeoA, which is encoded on a pathogenicity island and has been shown to enhance toxin release, potentially through vesicle secretion. By sequence comparisons and X-ray structure determination we now identify LeoA as a bacterial dynamin-like protein (DLP). Proteins of the dynamin family remodel membranes and were once thought to be restricted to eukaryotes. In ETEC H10407 LeoA localises to the periplasm where it forms a punc ...[more]
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