Ontology highlight
ABSTRACT:
SUBMITTER: Ourailidou ME
PROVIDER: S-EPMC4159585 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Chembiochem : a European journal of chemical biology 20131220 2
An increasing number of chemical reactions are being employed for bio-orthogonal ligation of detection labels to protein-bound functional groups. Several of these strategies, however, are limited in their application to pure proteins and are ineffective in complex biological samples such as cell lysates. Here we present the palladium-catalyzed oxidative Heck reaction as a new and robust bio-orthogonal strategy for linking functionalized arylboronic acids to protein-bound alkenes in high yields a ...[more]