Ontology highlight
ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC4159621 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Wang Yang Y Chen Dan D Qian Haili H Tsai Yihsuan S YS Shao Shujuan S Liu Quentin Q Dominguez Daniel D Wang Zefeng Z
Cancer cell 20140901 3
Splicing dysregulation is one of the molecular hallmarks of cancer. However, the underlying molecular mechanisms remain poorly defined. Here we report that the splicing factor RBM4 suppresses proliferation and migration of various cancer cells by specifically controlling cancer-related splicing. Particularly, RBM4 regulates Bcl-x splicing to induce apoptosis, and coexpression of Bcl-xL partially reverses the RBM4-mediated tumor suppression. Moreover, RBM4 antagonizes an oncogenic splicing factor ...[more]