Ontology highlight
ABSTRACT:
SUBMITTER: Pereira IT
PROVIDER: S-EPMC4160184 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Pereira Isabela T IT Ramos Edneia A S EA Costa Erico T ET Camargo Anamaria A AA Manica Graciele C M GC Klassen Liliane M B LM Chequin Andressa A Braun-Prado Karin K Pedrosa Fábio de O Fde O Souza Emanuel M EM Costa Fabricio F FF Klassen Giseli G
PloS one 20140910 9
Metastasis accounts for more than 90% of cancer deaths. Cells from primary solid tumors may invade adjacent tissues and migrate to distant sites where they establish new colonies. The tumor microenvironment is now recognized as an important participant in the signaling that induces cancer cell migration. An essential process for metastasis is extracellular matrix (ECM) degradation by metalloproteases (MMPs), which allows tumor cells to invade local tissues and to reach blood vessels. The members ...[more]