Ontology highlight
ABSTRACT:
SUBMITTER: Nandurkar NS
PROVIDER: S-EPMC4161159 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Nandurkar Nitin S NS Zhang Jianjun J Ye Qing Q Ponomareva Larissa V LV She Qing-Bai QB Thorson Jon S JS
Journal of medicinal chemistry 20140825 17
A facile route to perillyl alcohol (POH) differential glycosylation and the corresponding synthesis of a set of 34 POH glycosides is reported. Subsequent in vitro studies revealed a sugar dependent antiproliferative activity and the inhibition of S6 ribosomal protein phosphorylation as a putative mechanism of representative POH glycosides. The most active glycoside from this cumulative study (4'-azido-d-glucoside, PG9) represents one of the most cytotoxic POH analogues reported to date. ...[more]