Synthesis of novel perillyl-dihydropyrimidinone hybrids designed for antiproliferative activity.

ABSTRACT: A series of fifteen novel dihydropyrimidinone hybrid compounds were synthesized in good yields via a multicomponent reaction combined with the Huisgen reaction. The antiproliferative activity was investigated against nine tumor cell lines, and four hybrid compounds (TGI < 10 ?M) showed promising antiproliferative activity against the tumor cell lines OVCAR-3 (ovarian), UACC-62 (melanoma) and U251 (glioma). Several hybrid compounds assayed have high TGI values (TGI 147.92-507.82) for the human keratinocyte cell line (HaCat), which reveals selectivity to cancer cells.

SUBMITTER: Vendrusculo V 

PROVIDER: S-EPMC6151448 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature