Ontology highlight
ABSTRACT:
SUBMITTER: Vendrusculo V
PROVIDER: S-EPMC6151448 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
MedChemComm 20180731 9
A series of fifteen novel dihydropyrimidinone hybrid compounds were synthesized in good yields <i>via</i> a multicomponent reaction combined with the Huisgen reaction. The antiproliferative activity was investigated against nine tumor cell lines, and four hybrid compounds (TGI < 10 μM) showed promising antiproliferative activity against the tumor cell lines OVCAR-3 (ovarian), UACC-62 (melanoma) and U251 (glioma). Several hybrid compounds assayed have high TGI values (TGI 147.92-507.82) for the h ...[more]