Ontology highlight
ABSTRACT:
SUBMITTER: Kapere Ochieng J
PROVIDER: S-EPMC4161395 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Kapere Ochieng Joshua J Schilders Kim K Kool Heleen H Buscop-van Kempen Marjon M Boerema-De Munck Anne A Grosveld Frank F Wijnen Rene R Tibboel Dick D Rottier Robbert J RJ
PloS one 20140911 9
The adult lung contains several distinct stem cells, although their properties and full potential are still being sorted out. We previously showed that ectopic Sox2 expression in the developing lung manipulated the fate of differentiating cells. Here, we addressed the question whether fully differentiated cells could be redirected towards another cell type. Therefore, we used transgenic mice to express an inducible Sox2 construct in type II pneumocytes, which are situated in the distal, respirat ...[more]