Ontology highlight
ABSTRACT:
SUBMITTER: Rastogi A
PROVIDER: S-EPMC4162137 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Rastogi Anshu A Tan Shyh-Han SH Mohamed Ahmed A AA Chen Yongmei Y Hu Ying Y Petrovics Gyorgy G Sreenath Taduru T Kagan Jacob J Srivastava Sudhir S McLeod David G DG Sesterhenn Isabell A IA Srivastava Shiv S Dobi Albert A Srinivasan Alagarsamy A
Genes & cancer 20140701 7-8
The fusion between ERG coding sequences and the TMPRSS2 promoter is the most prevalent in prostate cancer (CaP). The presence of two main types of TMPRSS2-ERG fusion transcripts in CaP specimens, Type I and Type II, prompted us to hypothesize that the cumulative actions of different ERG variants may impact CaP development/progression. Using TMPRSS2-ERG3 (Type I) and TMPRSS2-ERG8 (Type II) expression vectors, we determined that the TMPRSS2- ERG8 encoded protein is deficient in transcriptional reg ...[more]