P53 dynamics control cell fate.
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ABSTRACT:
SUBMITTER: Purvis JE
PROVIDER: S-EPMC4162876 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Publications
p53 dynamics control cell fate.
Purvis Jeremy E JE Karhohs Kyle W KW Mock Caroline C Batchelor Eric E Loewer Alexander A Lahav Galit G
Science (New York, N.Y.) 20120601 6087
Cells transmit information through molecular signals that often show complex dynamical patterns. The dynamic behavior of the tumor suppressor p53 varies depending on the stimulus; in response to double-strand DNA breaks, it shows a series of repeated pulses. Using a computational model, we identified a sequence of precisely timed drug additions that alter p53 pulses to instead produce a sustained p53 response. This leads to the expression of a different set of downstream genes and also alters ce ...[more]
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