Ontology highlight
ABSTRACT:
SUBMITTER: Chen SC
PROVIDER: S-EPMC4163472 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Chen Sheng-Chia SC Huang Chi-Hung CH Yang Chia Shin CS Way Tzong-Der TD Chang Ming-Chung MC Chen Yeh Y
BioMed research international 20140827
RecQ DNA helicases are key enzymes in the maintenance of genome integrity, and they have functions in DNA replication, recombination, and repair. In contrast to most RecQs, RecQ from Deinococcus radiodurans (DrRecQ) possesses an unusual domain architecture that is crucial for its remarkable ability to repair DNA. Here, we determined the crystal structures of the DrRecQ helicase catalytic core and its ADP-bound form, revealing interdomain flexibility in its first RecA-like and winged-helix (WH) d ...[more]