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Structure of the manganese superoxide dismutase from Deinococcus radiodurans in two crystal forms.


ABSTRACT: The structure of the manganese superoxide dismutase (Mn-SOD; DR1279) from Deinococcus radiodurans has been determined in two different crystal forms. Both crystal forms are monoclinic with space group P2(1). Form I has unit-cell parameters a = 44.28, b = 83.21, c = 59.52 angstroms, beta = 110.18 degrees and contains a homodimer in the asymmetric unit, with structure refinement (R = 16.8%, R(free) = 23.6%) carried out using data to d(min) = 2.2 angstroms. Form II has unit-cell parameters a = 43.57, b = 87.10, c = 116.42 angstroms, beta = 92.1 degrees and an asymmetric unit containing two Mn-SOD homodimers; structure refinement was effected to a resolution of 2.0 angstroms (R = 17.2%, R(free) = 22.3%). The resulting structures are compared with that of Mn-SOD from Escherichia coli, with which they are shown to be essentially isostructural.

SUBMITTER: Dennis RJ 

PROVIDER: S-EPMC2222570 | biostudies-literature | 2006 Apr

REPOSITORIES: biostudies-literature

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Structure of the manganese superoxide dismutase from Deinococcus radiodurans in two crystal forms.

Dennis Rebecca J RJ   Micossi Elena E   McCarthy Joanne J   Moe Elin E   Gordon Elspeth J EJ   Kozielski-Stuhrmann Sigrid S   Leonard Gordon A GA   McSweeney Sean S  

Acta crystallographica. Section F, Structural biology and crystallization communications 20060325 Pt 4


The structure of the manganese superoxide dismutase (Mn-SOD; DR1279) from Deinococcus radiodurans has been determined in two different crystal forms. Both crystal forms are monoclinic with space group P2(1). Form I has unit-cell parameters a = 44.28, b = 83.21, c = 59.52 angstroms, beta = 110.18 degrees and contains a homodimer in the asymmetric unit, with structure refinement (R = 16.8%, R(free) = 23.6%) carried out using data to d(min) = 2.2 angstroms. Form II has unit-cell parameters a = 43.5  ...[more]

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