Ontology highlight
ABSTRACT:
SUBMITTER: Shen QT
PROVIDER: S-EPMC4164947 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Shen Qing-Tao QT Schuh Amber L AL Zheng Yuqing Y Quinney Kyle K Wang Lei L Hanna Michael M Mitchell Julie C JC Otegui Marisa S MS Ahlquist Paul P Cui Qiang Q Audhya Anjon A
The Journal of cell biology 20140908 6
The scission of biological membranes is facilitated by a variety of protein complexes that bind and manipulate lipid bilayers. ESCRT-III (endosomal sorting complex required for transport III) filaments mediate membrane scission during the ostensibly disparate processes of multivesicular endosome biogenesis, cytokinesis, and retroviral budding. However, mechanisms by which ESCRT-III subunits assemble into a polymer remain unknown. Using cryogenic electron microscopy (cryo-EM), we found that the f ...[more]