Ontology highlight
ABSTRACT:
SUBMITTER: Yan J
PROVIDER: S-EPMC4165194 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Yan Jun J Yan Feng F Li Zhijun Z Sinnott Becky B Cappell Kathryn M KM Yu Yanbao Y Mo Jinyao J Duncan Joseph A JA Chen Xian X Cormier-Daire Valerie V Whitehurst Angelique W AW Xiong Yue Y
Molecular cell 20140501 5
CUL7, OBSL1, and CCDC8 genes are mutated in a mutually exclusive manner in 3M and other growth retardation syndromes. The mechanism underlying the function of the three 3M genes in development is not known. We found that OBSL1 and CCDC8 form a complex with CUL7 and regulate the level and centrosomal localization of CUL7, respectively. CUL7 depletion results in altered microtubule dynamics, prometaphase arrest, tetraploidy, and mitotic cell death. These defects are recaptured in CUL7 mutated 3M c ...[more]