Ontology highlight
ABSTRACT:
SUBMITTER: Li Z
PROVIDER: S-EPMC4172312 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Li Zhijun Z Pei Xin-Hai XH Yan Jun J Yan Feng F Cappell Kathryn M KM Whitehurst Angelique W AW Xiong Yue Y
Molecular cell 20140501 5
The Cullin 9 (CUL9) gene encodes a putative E3 ligase that localizes in the cytoplasm. Cul9 null mice develop spontaneous tumors in multiple organs; however, both the cellular and the molecular mechanisms of CUL9 in tumor suppression are currently unknown. We show here that deletion of Cul9 leads to abnormal nuclear morphology, increased DNA damage, and aneuploidy. CUL9 knockdown rescues the microtubule and mitosis defects in cells depleted for CUL7 or OBSL1, two genes that are mutated in a mutu ...[more]