Ontology highlight
ABSTRACT:
SUBMITTER: Yu X
PROVIDER: S-EPMC4165400 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Yu Xiaofei X Rollins Darcy D Ruhn Kelly A KA Stubblefield Jeremy J JJ Green Carla B CB Kashiwada Masaki M Rothman Paul B PB Takahashi Joseph S JS Hooper Lora V LV
Science (New York, N.Y.) 20131101 6159
Circadian clocks regulate numerous physiological processes that vary across the day-night (diurnal) cycle, but if and how the circadian clock regulates the adaptive immune system is mostly unclear. Interleukin-17-producing CD4(+) T helper (T(H)17) cells are proinflammatory immune cells that protect against bacterial and fungal infections at mucosal surfaces. Their lineage specification is regulated by the orphan nuclear receptor RORγt. We show that the transcription factor NFIL3 suppresses T(H)1 ...[more]