Novel nuclear herniations induced by nuclear localization of a viral protein.
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ABSTRACT:
SUBMITTER: Hoyt CC
PROVIDER: S-EPMC416550 | biostudies-literature | 2004 Jun
REPOSITORIES: biostudies-literature
Publications
Novel nuclear herniations induced by nuclear localization of a viral protein.
Hoyt Cristen C CC Bouchard Ron J RJ Tyler Kenneth L KL
Journal of virology 20040601 12
A common consequence of viral infection is perturbation of host cell nuclear functions. For cytoplasmically replicating viruses, this process may require regulated transport of specific viral proteins into the nucleus. Here, we describe a novel form of virus-induced perturbation of host cell nuclear structures. Active signal-mediated nuclear import of the reovirus sigma1s protein results in redistribution of nuclear pore complexes and nuclear lamins and formation of nuclear herniations. These he ...[more]
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