Ontology highlight
ABSTRACT:
SUBMITTER: Kim SC
PROVIDER: S-EPMC4166787 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Kim Seong Chul SC Kellett Thomas T Wang Shaohua S Nishi Miyuki M Nagre Nagaraja N Zhou Beiyun B Flodby Per P Shilo Konstantin K Ghadiali Samir N SN Takeshima Hiroshi H Hubmayr Rolf D RD Zhao Xiaoli X
American journal of physiology. Lung cellular and molecular physiology 20140808 6
The molecular mechanisms for lung cell repair are largely unknown. Previous studies identified tripartite motif protein 72 (TRIM72) from striated muscle and linked its function to tissue repair. In this study, we characterized TRIM72 expression in lung tissues and investigated the role of TRIM72 in repair of alveolar epithelial cells. In vivo injury of lung cells was introduced by high tidal volume ventilation, and repair-defective cells were labeled with postinjury administration of propidium i ...[more]