Ontology highlight
ABSTRACT:
SUBMITTER: Sun T
PROVIDER: S-EPMC6675554 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Sun Tianhe T Huang Zhiyu Z Zhang Hua H Posner Clara C Jia Guiquan G Ramalingam Thirumalai R TR Xu Min M Brightbill Hans H Egen Jackson G JG Dey Anwesha A Arron Joseph R JR
JCI insight 20190618
The lung is a relatively quiescent organ during homeostasis, but has a remarkable capacity for repair after injury. Alveolar epithelial type I cells (AEC1s) line airspaces and mediate gas exchange. After injury, they are regenerated by differentiation from their progenitors - alveolar epithelial type II cells (AEC2s) - which also secrete surfactant to maintain surface tension and alveolar patency. While recent studies showed that the maintenance of AEC2 stemness is Wnt dependent, the molecular m ...[more]