Ontology highlight
ABSTRACT:
SUBMITTER: Grieschat M
PROVIDER: S-EPMC4167291 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Grieschat Matthias M Alekov Alexi K AK
Biophysical journal 20140901 6
Most mammalian chloride channels and transporters in the CLC family display pronounced voltage-dependent gating. Surprisingly, despite the complex nature of the gating process and the large contribution to it by the transport substrates, experimental investigations of the fast gating process usually produce canonical Boltzmann activation curves that correspond to a simple two-state activation. By using nonlinear capacitance measurements of two mutations in the ClC-5 transporter, here we are able ...[more]