Ontology highlight
ABSTRACT:
SUBMITTER: Lim HH
PROVIDER: S-EPMC3805709 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Lim Hyun-Ho HH Stockbridge Randy B RB Miller Christopher C
Nature chemical biology 20130915 11
Cl(-)/H(+) antiporters of the CLC superfamily transport anions across biological membranes in varied physiological contexts. These proteins are weakly selective among anions commonly studied, including Cl(-), Br(-), I(-), NO3(-) and SCN(-), but they seem to be very selective against F(-). The recent discovery of a new CLC clade of F(-)/H(+) antiporters, which are highly selective for F(-) over Cl(-), led us to investigate the mechanism of Cl(-)-over-F(-) selectivity by a CLC Cl(-)/H(+) antiporte ...[more]