Ontology highlight
ABSTRACT:
SUBMITTER: Nishio N
PROVIDER: S-EPMC4167556 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Nishio Nobuhiro N Diaconu Iulia I Liu Hao H Cerullo Vincenzo V Caruana Ignazio I Hoyos Valentina V Bouchier-Hayes Lisa L Savoldo Barbara B Dotti Gianpietro G
Cancer research 20140724 18
The clinical efficacy of chimeric antigen receptor (CAR)-redirected T cells remains marginal in solid tumors compared with leukemias. Failures have been attributed to insufficient T-cell migration and to the highly immunosuppressive milieu of solid tumors. To overcome these obstacles, we have combined CAR-T cells with an oncolytic virus armed with the chemokine RANTES and the cytokine IL15, reasoning that the modified oncolytic virus will both have a direct lytic effect on infected malignant cel ...[more]