Ontology highlight
ABSTRACT:
SUBMITTER: Zhang E
PROVIDER: S-EPMC5767005 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Zhang Erhao E Gu Jieyi J Xu Hanmei H
Molecular cancer 20180112 1
The potential for adoptive cell immunotherapy as a treatment against cancers has been demonstrated by the remarkable response in some patients with hematological malignancies using autologous T cells endowed with chimeric antigen receptors (CARs) specific for CD19. Clinical efficacy of CAR-T cell therapy for the treatment of solid tumors, however, is rare due to physical and biochemical factors. This review focuses on different aspects of multiple mechanisms of immunosuppression in solid tumors. ...[more]