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Thymic self-reactivity selects natural interleukin 17-producing T cells that can regulate peripheral inflammation.

ABSTRACT: Interleukin 17 (IL-17)-producing CD4(+) helper T cells (T(H)-17 cells) share a developmental relationship with Foxp3(+) regulatory T cells (T(reg) cells). Here we show that a T(H)-17 population differentiates in the thymus in a manner influenced by recognition of self antigen and by the cytokines IL-6 and transforming growth factor-beta (TGF-beta). Like previously described T(H)-17 cells, the T(H)-17 cells that developed in the thymus expressed the transcription factor RORgamma t and the IL-23 receptor. These cells also expressed alpha(4)beta(1) integrins and the chemokine receptor CCR6 and were recruited to the lung, gut and liver. In the liver, these cells secreted IL-22 in response to self antigen and mediated host protection during inflammation. Thus, T(H)-17 cells, like T(reg) cells, can be selected by self antigens in the thymus.

SUBMITTER: Marks BR

PROVIDER: S-EPMC2751862 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature

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Thymic self-reactivity selects natural interleukin 17-producing T cells that can regulate peripheral inflammation.

Marks Benjamin R BR Nowyhed Heba N HN Choi Jin-Young JY Poholek Amanda C AC Odegard Jared M JM Flavell Richard A RA Craft Joe J

Nature immunology 20090906 10

Interleukin 17 (IL-17)-producing CD4(+) helper T cells (T(H)-17 cells) share a developmental relationship with Foxp3(+) regulatory T cells (T(reg) cells). Here we show that a T(H)-17 population differentiates in the thymus in a manner influenced by recognition of self antigen and by the cytokines IL-6 and transforming growth factor-beta (TGF-beta). Like previously described T(H)-17 cells, the T(H)-17 cells that developed in the thymus expressed the transcription factor RORgamma t and the IL-23 r ...[more]

PMID: 19734905

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