Case report: stimulation of the right amygdala induces transient changes in affective bias.

ABSTRACT: Sensitive outcome measures are needed to quantify the effects of neuromodulation in mood disorders.This study examined the utility of a novel affective bias (AB) task in identifying transient mood changes induced by amygdala stimulation in a single rare participant.Localized, pulsed electrical stimulation was delivered for 8 min during measures of AB and self-reported mood. Responses were compared with those gathered without stimulation on the same day in the same setting, using paired t-tests.Stimulation of the basolateral nucleus of the right amygdala at 50 Hz, 15 V, and 200 ?s pulse-width produced a significant positive shift in AB (t = -2.864, df = 53, P = .006), despite equivocal findings on self-reported mood (t = -.184, df = 12, P = .857).Affective bias may be more sensitive to stimulation-induced fluctuations in mood than subjective report, suggesting utility as an outcome measure in neuromodulation studies.

SUBMITTER: Bijanki KR 

PROVIDER: S-EPMC4167906 | biostudies-literature | 2014 Sep-Oct

REPOSITORIES: biostudies-literature