Ontology highlight
ABSTRACT:
SUBMITTER: Al-Edani T
PROVIDER: S-EPMC4168028 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Al-Edani Tamadir T Al-Edani Tamadir T Assou Said S Ferrières Alice A Bringer Deutsch Sophie S Gala Anna A Lecellier Charles-Henri CH Aït-Ahmed Ounissa O Hamamah Samir S
BioMed research international 20140903
Impact of female aging is an important issue in human reproduction. There was a need for an extensive analysis of age impact on transcriptome profile of cumulus cells (CCs) to link oocyte quality and developmental potential with patient's age. CCs from patients of three age groups were analyzed individually using microarrays. RT-qPCR validation was performed on independent CC cohorts. We focused here on pathways affected by aging in CCs that may explain the decline of oocyte quality with age. In ...[more]