Ontology highlight
ABSTRACT:
SUBMITTER: Snyder JM
PROVIDER: S-EPMC4168129 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Snyder Jessica M JM Treuting Piper M PM Nagy Lee L Yam Cathy C Yi Jaehun J Brasfield Alicia A Nguyen Lisa Phuong Anh LP Hajjar Adeline M AM
PloS one 20140917 9
A humanized TLR7/TLR8 transgenic mouse line was engineered for studies using TLR7/8 ligands as vaccine adjuvants. The mice developed a spontaneous immune-mediated phenotype prior to six months of age characterized by runting, lethargy, blepharitis, and corneal ulceration. Histological examination revealed a marked, multisystemic histiocytic infiltrate that effaced normal architecture. The histological changes were distinct from those previously reported in mouse models of systemic lupus erythema ...[more]