A biochemical characterization of the DNA binding activity of the response regulator VicR from Streptococcus mutans.
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ABSTRACT:
SUBMITTER: Ayala E
PROVIDER: S-EPMC4168254 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
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A biochemical characterization of the DNA binding activity of the response regulator VicR from Streptococcus mutans.
Ayala Eduardo E Downey Jennifer S JS Mashburn-Warren Lauren L Senadheera Dilani B DB Cvitkovitch Dennis G DG Goodman Steven D SD
PloS one 20140917 9
Two-component systems (TCSs) are ubiquitous among bacteria and are among the most elegant and effective sensing systems in nature. They allow for efficient adaptive responses to rapidly changing environmental conditions. In this study, we investigated the biochemical characteristics of the Streptococcus mutans protein VicR, an essential response regulator that is part of the VicRK TCS. We dissected the DNA binding requirements of the recognition sequences for VicR in its phosphorylated and unpho ...[more]
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