Oxazinin A, a pseudodimeric natural product of mixed biosynthetic origin from a filamentous fungus.
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ABSTRACT:
SUBMITTER: Lin Z
PROVIDER: S-EPMC4168773 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Publications
Oxazinin A, a pseudodimeric natural product of mixed biosynthetic origin from a filamentous fungus.
Lin Zhenjian Z Koch Michael M Abdel Aziz May Hamdy MH Galindo-Murillo Rodrigo R Tianero Ma Diarey MD Cheatham Thomas E TE Barrows Louis R LR Reilly Chris A CA Schmidt Eric W EW
Organic letters 20140904 18
A racemic, prenylated polyketide dimer, oxazinin A (1), was isolated from a novel filamentous fungus in the class Eurotiomycetes, and its structure was elucidated spectroscopically. The pentacyclic structure of oxazinin A (1) is a unique combination of benzoxazine, isoquinoline, and a pyran ring. Oxazinin A (1) exhibited antimycobacterial activity and modestly antagonized transient receptor potential (TRP) channels. ...[more]
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