Ontology highlight
ABSTRACT:
SUBMITTER: Bionda N
PROVIDER: S-EPMC4168796 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
ACS chemical biology 20140801 9
Inspired by the biosynthetic logic of lanthipeptide natural products, a new methodology was developed to direct the ribosomal synthesis of macrocyclic peptides constrained by an intramolecular thioether bond. As a first step, a robust and versatile strategy was implemented to enable the cyclization of ribosomally derived peptide sequences via a chemoselective reaction between a genetically encoded cysteine and a cysteine-reactive unnatural amino acid (O-(2-bromoethyl)-tyrosine). Combination of t ...[more]