Ontology highlight
ABSTRACT:
SUBMITTER: Frost JR
PROVIDER: S-EPMC4546577 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Frost John R JR Jacob Nicholas T NT Papa Louis J LJ Owens Andrew E AE Fasan Rudi R
ACS chemical biology 20150515 8
A versatile method for orchestrating the formation of side chain-to-tail cyclic peptides from ribosomally derived polypeptide precursors is reported. Upon ribosomal incorporation into intein-containing precursor proteins, designer unnatural amino acids bearing side chain 1,3- or 1,2-aminothiol functionalities are able to promote the cyclization of a downstream target peptide sequence via a C-terminal ligation/ring contraction mechanism. Using this approach, peptide macrocycles of variable size a ...[more]