Radium-223 dichloride bone-targeted alpha particle therapy for hormone-refractory breast cancer metastatic to bone.
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ABSTRACT:
SUBMITTER: Takalkar A
PROVIDER: S-EPMC4168986 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
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Radium-223 dichloride bone-targeted alpha particle therapy for hormone-refractory breast cancer metastatic to bone.
Takalkar Amol A Adams Scott S Subbiah Vivek V
Experimental hematology & oncology 20140908
<h4>Background</h4>Hormone-refractory breast cancer metastatic to bone is a clinically challenging disease associated with high morbidity, poor prognosis, and impaired quality of life owing to pain and skeletal-related events. In a preclinical study using a mouse model of breast cancer and bone metastases, Ra-223 dichloride was incorporated into bone matrix and inhibited proliferation of breast cancer cells and differentiation of osteoblasts and osteoclasts (all P values < .001) in vitro. Ra-223 ...[more]
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