Ontology highlight
ABSTRACT:
SUBMITTER: Kong Q
PROVIDER: S-EPMC4169413 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Kong Qingran Q Hai Tang T Ma Jing J Huang Tianqing T Jiang Dandan D Xie Bingteng B Wu Meiling M Wang Jiaqiang J Song Yuran Y Wang Ying Y He Yilong Y Sun Jialu J Hu Kui K Guo Runfa R Wang Liu L Zhou Qi Q Mu Yanshuang Y Liu Zhonghua Z
PloS one 20140918 9
Genetically modified pigs have become a popular model system in fundamental research, agricultural and biomedical applications. However, random integration often result in unstable expression of transgene and unpredictable phenotypes. The Rosa26 locus has been widely used to produce genetic modified animals with high and consistent expressing of transgene in mouse, human and rat, as it can be targeted efficiently and is not subject to gene-silencing effects. Recently, the first case of reporter ...[more]