Ontology highlight
ABSTRACT:
SUBMITTER: Cheng EC
PROVIDER: S-EPMC4169525 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Cheng Ee-Chun EC Kang Dongwan D Wang Zhong Z Lin Haifan H
PloS one 20140919 9
PIWI proteins play essential and conserved roles in germline development, including germline stem cell maintenance and meiosis. Because germline regulators such as OCT4, NANOG, and SOX2 are known to be potent factors that reprogram differentiated somatic cells into induced pluripotent stem cells (iPSCs), we investigated whether the PIWI protein family is involved in iPSC production. We find that all three mouse Piwi genes, Miwi, Mili, and Miwi2, are expressed in embryonic stem cells (ESCs) at hi ...[more]