Ontology highlight
ABSTRACT:
SUBMITTER: Mathew R
PROVIDER: S-EPMC4169768 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Mathew Robin R Khor Sinan S Hackett Sean R SR Rabinowitz Joshua D JD Perlman David H DH White Eileen E
Molecular cell 20140828 6
Ras-driven cancer cells upregulate basal autophagy that degrades and recycles intracellular proteins and organelles. Autophagy-mediated proteome degradation provides free amino acids to support metabolism and macromolecular synthesis, which confers a survival advantage in starvation and promotes tumorigenesis. While the degradation of isolated protein substrates by autophagy has been implicated in controlling cellular function, the extent and specificity by which autophagy remodels the cellular ...[more]