Ontology highlight
ABSTRACT:
SUBMITTER: Wang S
PROVIDER: S-EPMC4820827 | biostudies-other | 2016 Mar
REPOSITORIES: biostudies-other
Wang Shuo S Xia Pengyan P Huang Guanling G Zhu Pingping P Liu Jing J Ye Buqing B Du Ying Y Fan Zusen Z
Nature communications 20160324
Natural killer (NK) cells exert a crucial role in early immune responses as a major innate effector component. However, the underlying mechanisms of NK cell development remain largely elusive. Here we show that robust autophagy appears in the stage of immature NK cells (iNKs), which is required for NK cell development. Autophagy defects result in damaged mitochondria and accumulation of reactive oxygen species (ROS) that leads to apoptosis of NK cells. Autophagy protects NK cell viability during ...[more]