Ontology highlight
ABSTRACT:
SUBMITTER: Weng L
PROVIDER: S-EPMC4170004 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Weng Leiyun L Mitoma Hiroki H Trichot Coline C Bao Musheng M Liu Ying Y Zhang Zhiqiang Z Liu Yong-Jun YJ
Journal of immunology (Baltimore, Md. : 1950) 20140829 7
NLRP3 is a key component of caspase-activating macromolecular protein complexes called inflammasomes. It has been found that DHX33 is a cytosolic dsRNA sensor for the NLRP3 inflammasome, which induces caspase-1-dependent production of IL-1β and IL-18 upon activation. However, how the cytosolic dsRNAs induce the interaction between DHX33 and the NLRP3 inflammasome remains unknown. In this study, we report that TRIM33, a member of the tripartite motif (TRIM) family, can bind DHX33 directly and ind ...[more]