Ontology highlight
ABSTRACT:
SUBMITTER: Felices M
PROVIDER: S-EPMC4170052 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Felices Martin M Ankarlo Dave E M DE Lenvik Todd R TR Nelson Heather H HH Blazar Bruce R BR Verneris Michael R MR Miller Jeffrey S JS
Journal of immunology (Baltimore, Md. : 1950) 20140829 7
The Notch signaling pathway plays a substantial role in human NK cell development. However, the role of Notch on killer Ig-like receptor (KIR) upregulation and acquisition of effector function has not been explored. To evaluate how Notch influences terminal differentiation, cord blood-derived NK cells or sorted peripheral blood NK cells were cultured with IL-15 for 7 d with inhibitory or activating Notch signals. Inhibition of Notch signaling significantly decreased KIR expression, whereas activ ...[more]