Ontology highlight
ABSTRACT:
SUBMITTER: Gahan JM
PROVIDER: S-EPMC5526613 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Gahan James M JM Schnitzler Christine E CE DuBuc Timothy Q TQ Doonan Liam B LB Kanska Justyna J Gornik Sebastian G SG Barreira Sofia S Thompson Kerry K Schiffer Philipp P Baxevanis Andreas D AD Frank Uri U
Developmental biology 20170607 1
The function of Notch signaling was previously studied in two cnidarians, Hydra and Nematostella, representing the lineages Hydrozoa and Anthozoa, respectively. Using pharmacological inhibition in Hydra and a combination of pharmacological and genetic approaches in Nematostella, it was shown in both animals that Notch is required for tentacle morphogenesis and for late stages of stinging cell maturation. Surprisingly, a role for Notch in neural development, which is well documented in bilaterian ...[more]