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Fast and versatile fabrication of PMMA microchip electrophoretic devices by laser engraving.


ABSTRACT: This paper describes the effects of different modes and engraving parameters on the dimensions of microfluidic structures produced in PMMA using laser engraving. The engraving modes included raster and vector, while the explored engraving parameters included power, speed, frequency, resolution, line-width, and number of passes. Under the optimum conditions, the technique was applied to produce channels suitable for CE separations. Taking advantage of the possibility to cut-through the substrates, the laser was also used to define solution reservoirs (buffer, sample, and waste) and a PDMS-based decoupler. The final device was used to perform the analysis of a model mixture of phenolic compounds within 200 s with baseline resolution.

SUBMITTER: Moreira Gabriel EF 

PROVIDER: S-EPMC4170527 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature

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Fast and versatile fabrication of PMMA microchip electrophoretic devices by laser engraving.

Moreira Gabriel Ellen Flávia EF   Tomazelli Coltro Wendell Karlos WK   Garcia Carlos D CD  

Electrophoresis 20140801 16


This paper describes the effects of different modes and engraving parameters on the dimensions of microfluidic structures produced in PMMA using laser engraving. The engraving modes included raster and vector, while the explored engraving parameters included power, speed, frequency, resolution, line-width, and number of passes. Under the optimum conditions, the technique was applied to produce channels suitable for CE separations. Taking advantage of the possibility to cut-through the substrates  ...[more]

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